Research field

Gerontology

Gerontology is the multidisciplinary study of the biological, psychological, and social dimensions of aging—seeking to understand why organisms age, what molecular and cellular mechanisms drive age-related decline, and how interventions might extend healthspan and reduce the burden of age-associated diseases including neurodegeneration, cardiovascular disease, cancer, and metabolic dysfunction. At the cellular level, hallmarks of aging—telomere attrition, epigenetic drift, mitochondrial dysfunction, cellular senescence, and stem cell exhaustion—have been identified and are being targeted by senolytic drugs that selectively eliminate senescent cells, caloric restriction mimetics, and pathway modulators such as rapamycin and metformin. Longitudinal cohort studies follow aging populations over decades to connect lifestyle, genetics, and environment to health outcomes, while epigenetic clocks provide precise biological age estimates from DNA methylation patterns. Gerontology integrates basic biology with geriatric medicine, health economics, and social policy as societies face rapidly increasing proportions of older adults globally.

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